HBOT research library

Hyperbaric oxygen therapy research, in plain language.

Looking for HBOT case studies? We replaced patient stories with something more useful: published studies and reviews, each with a one-line takeaway and its limits, plus a short guide to reading research yourself.

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A research library, not patient stories.

Hyperbaric oxygen therapy research ranges from large reviews to small pilot studies. A single patient case can be interesting, but it cannot tell you whether HBOT would help you. So this page links to real, published work across wound healing, radiation injury, sudden hearing loss, carbon monoxide poisoning, post-concussion symptoms and cognition.

Suntree does not share testimonials or outcome figures about its own guests. Each study below is linked so you can read the abstract and bring questions to the team and your physician.

Established uses and research questions are different.

HBOT has a short list of uses that the FDA has cleared for hyperbaric chambers and that the UHMS recognizes, including selected non-healing diabetic wounds, delayed radiation injury, carbon monoxide poisoning and sudden sensorineural hearing loss. Our wound healing page covers one of these areas.

Everything else is off-label or investigational. Researchers are studying HBOT for concussion and neurological symptoms and for cognitive questions, but it is not FDA-cleared for these uses, and results vary. You can browse every topic from the HBOT benefits overview.

How to read a study.

A few questions help you judge how much weight a result can carry.

  • Randomized or not? In a randomized trial, chance decides who gets HBOT. That makes the groups more comparable. Pilot and observational studies are useful for ideas, but weaker as evidence.
  • Was there a sham? A sham group sits in the chamber at minimal pressure without extra oxygen. Without one, expectation and extra attention can look like a treatment effect.
  • How many people? Small studies can produce large effects by chance. Results from a few dozen people need confirmation.
  • How long was follow-up? Changes measured a few weeks after the last session may not last.
  • Review or single trial? A systematic review, such as a Cochrane review, pools several trials and rates their quality.

What the FDA says.

The FDA has published a consumer caution about HBOT claims for conditions such as Alzheimer's disease, autism, depression, stroke, sports injuries and others outside the cleared list. It encourages people to talk with their health care provider about any treatment claim. We think that is sound advice for every study on this page.

Emergencies belong in a hospital.

Carbon monoxide poisoning, decompression sickness and gas embolism are medical emergencies treated in hospital chambers. If you suspect one, call 911. Suntree is a wellness center in Rockledge, not an emergency facility.

Bring the study to a conversation.

If a study caught your attention, bring it to your physician and to the Suntree team. Before any first session, the team reviews your health history. HBOT is not right for everyone: ear or sinus problems, a history of collapsed lung, pregnancy, some medications and claustrophobia all need discussion first.

The library

Ten studies. Read the source.

Each summary includes the limits. Research context is not a promise that HBOT is appropriate for you or will produce a particular result.

Diabetes Care · 2010

Randomized trial in chronic diabetic foot ulcers

In 94 patients, 40 daily sessions of HBOT or placebo were added to standard wound care. At one year, 52% of the HBOT group had healed ulcers compared with 29% on placebo. A single center, with selected patients.

PubMed abstract
Cochrane Review · 2015

Systematic review of HBOT for chronic wounds

Across 12 trials with 577 people, HBOT improved diabetic foot ulcer healing in the short term but not clearly in the long term. Design flaws limited confidence, and there was no evidence for arterial or pressure ulcers.

PubMed abstract
Cochrane Review · 2016

Review of HBOT for late radiation tissue injury

Fourteen trials (753 people) suggested benefit for some late radiation injuries of the head, neck, anus and rectum. The authors called for more research on which patients benefit and when.

PubMed abstract
Int J Radiat Oncol Biol Phys · 2019

HOPON: HBOT before dental surgery in irradiated jaws

In a randomized trial of 144 people, HBOT before dental surgery did not reduce jaw osteoradionecrosis, which was uncommon in both groups. A useful reminder that results differ by situation.

Journal abstract
Cochrane Review · 2012

HBOT for sudden sensorineural hearing loss

Seven trials (392 people) found improved hearing when HBOT started early in acute cases, but the clinical meaning was unclear. There was no evidence of benefit for long-standing hearing loss or tinnitus.

PubMed abstract
New England Journal of Medicine · 2002

Carbon monoxide poisoning: three hospital sessions

In 152 patients, three hyperbaric sessions within 24 hours were followed by fewer cognitive problems at six weeks than normobaric oxygen. This is emergency hospital care, and the trial stopped early.

Journal article
JAMA Internal Medicine · 2015

Sham-controlled trial for persistent post-concussion symptoms

In 72 service members, 40 sessions of HBOT showed no benefit over sham chamber sessions. Both chamber groups improved more than usual care alone, which the authors linked to placebo-type effects.

PubMed abstract
PLOS ONE · 2013

Crossover trial of HBOT years after mild brain injury

In 56 people with lasting post-concussion symptoms, 40 sessions were followed by better cognitive scores and quality of life. There was no sham group, so expectation effects cannot be ruled out.

Journal article
Aging · 2020

Cognitive testing in healthy older adults

In 63 adults, 60 sessions over three months were followed by better attention and processing speed than in a control group. The control group had no sham sessions, and participants were not blinded.

Journal article
Scientific Reports · 2022

Sham-controlled trial in post-COVID cognitive symptoms

In 73 patients, 40 sessions were followed by better cognitive and symptom scores than sham. The sample was small and follow-up was only a few weeks, so how long any effect lasts is unknown.

Journal article

Good questions

Know what to expect.

Questions about your health history or goals are best answered by phone with the Suntree team.

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Why doesn't this page share patient success stories?

Individual stories cannot show whether a result came from HBOT, from time, from other care, or from expectation. Published studies with comparison groups are a better guide. Suntree does not publish testimonials or outcome figures, and the team will talk with you about realistic expectations for your situation.

Does a positive study mean HBOT will work for me?

No. A study describes an average result in a specific group, at a specific pressure and schedule. Your health history, goals and response may be different. Results vary, and some well-designed trials found no benefit. Talk with your physician and the team before deciding.

What is a sham-controlled HBOT trial?

In a sham-controlled trial, the comparison group also enters the chamber, but at minimal pressure and without extra oxygen, and participants do not know which group they are in. This helps separate the effect of oxygen under pressure from the effect of the experience itself.

Are the concussion and cognition findings settled?

No. Some studies report improvements, while a sham-controlled trial in service members found no benefit over sham. Many studies were small or lacked a sham group. HBOT is not FDA-cleared for these uses, and researchers are still studying them.

Can I bring a study to my first conversation with the team?

Yes, please do. Bring the link or a printout when you call or visit. The team can explain how the study's pressure, session length and schedule compare with sessions in Rockledge, and your physician can help you weigh the findings against your own health history.

Have a study you want to talk through?

Call the Rockledge team to discuss suitability, realistic expectations, and whether HBOT may fit your goals.

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